78860-03-4

Basic information

• Product Name: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• CAS NO: 78860-03-4
• Molecular Formula: C₁₇H₁₂N₂O
• Molecular Weight: 260.29
• Mol File: 78860-03-4.mol

Chemical Properties

• Boiling Point: 414.8°C at 760 mmHg
• Flash Point: 204.6°C
• Density: 1.27g/cm³
• Vapor Pressure: 4.34E-07mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carbonitrile(78860-03-4)
• EPA Substance Registry System: 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carbonitrile(78860-03-4)

Safety Data

• Hazardous Substances Data: 78860-03-4(Hazardous Substances Data)

Usage

Physical state

Yellow solid

Applications

Research and pharmaceutical

Structural features

a. Quinoline ring
b. Benzyl group
c. Cyano group at the 3-carbon position

Potential biological activities

a. Anti-cancer
b. Anti-inflammatory
c. Antimicrobial

Significance

Promising compound for further research and development in medicinal chemistry

Upstream product

• 1353669-36-9 methyl 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 61707-79-7 1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid methyl ester 
• 38238-86-7 dimethyl 2-phenylaminoethylene-1,1-dicarboxylate 
• 62-53-3 aniline 
• 91420-16-5 1-benzyl-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 78873-55-9 4,4'-Oxydi-(1-benzyl-1,4-dihydro-3-chinolincarbonitril) 
• 78859-98-0 1-Benzyl-4-ethoxy-1,4-dihydro-3-chinolincarbonitril 

Relevant articles and documents

Tetrazole substituted quinolinone derivative and preparation method and application thereof

The invention discloses a tetrazole substituted quinolinone derivative and a preparation method and application thereof, and belongs to the technical field of organic compound preparation. The structure of the compound is shown as a formula (I) or pharmaceutically acceptable salt thereof, and in the formula, R1 is tetrazole, R2 is a hydrogen atom or a halogen atom, and R3 is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group. The product disclosed by the invention is a high-efficiency aldose reductase inhibitor with excellent membrane permeability, and the in-vivo availability of the inhibitor can be improved, so that the effect of treating diabetic complications is achieved.

Pseudobases from Quinolinium-Salts and Alcoxides

The quaternary 3-cyano-quinolinium salt (1b) reacts in aqueous buffer solution (pH 7.5-12) to oxy-di(1,4-dihydroquinoline) (7), which gives on addition of alcohols or oximes in high yields the alcoxy-dihydroquinolines (8a-c) or dihydroquinolyl-oximethers (8d-f). - Key words: Quinolinium Salts, Pseudobases, Insertion Reaction