78862-76-7Relevant academic research and scientific papers
Synthesis and structure-activity evaluation of isatin-β- thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein
Hall, Matthew D.,Brimacombe, Kyle R.,Varonka, Matthew S.,Pluchino, Kristen M.,Monda, Julie K.,Li, Jiayang,Walsh, Martin J.,Boxer, Matthew B.,Warren, Timothy H.,Fales, Henry M.,Gottesman, Michael M.
experimental part, p. 5878 - 5889 (2011/10/08)
Cancer multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters presents a significant unresolved clinical challenge. One strategy to resolve MDR is to develop compounds that selectively kill cells overexpressing the efflux transport
Synthesis and antibacterial activity of thiosemicarbazones
Parekh,Desai
, p. 1072 - 1075 (2007/10/03)
The synthesis of 1-[(2′-hydroxy-4′-isopropoxy-5′- nitrophenyl)-ethanone]-4-(aryl)-3-thiosemicarbazones are carried out by refluxing 4-aryl-3-thiosemicarbazides and 2-hydroxy-4-isopropoxy-5- nitroacetophenone in stoichiometric amounts dissolved in aqueous
