78874-31-4

Upstream product

• 29203-60-9 2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride 
• 378205-20-0 ethyl 3-(2,4-dichlorophenyl)isoxazole-5-carboxylate 
• 140946-55-0 C₁₂H₁₁Cl₂NO₃ 
• 57045-35-9 (E)-4-(2,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid 
• 215319-12-3 3-(2,4-dichlorophenyl)-5-hydroxymethylisoxazole 
• 78874-40-5 4-(2,4-Dichloro-phenyl)-3-hydroxy-2-morpholin-4-yl-4-oxo-butyric acid 
• 78874-14-3 3-(2,4-Dichloro-benzoyl)-oxirane-2-carboxylic acid 

Downstream Products

• 1235471-25-6 3-(2,4-dichlorophenyl)isoxazole-5-carboxylic acid 4-bromophenylamide 
• 1235471-26-7 3-(2,4-dichlorophenyl)isoxazole-5-carboxylic acid 4-methoxyphenylamide 

Relevant academic research and scientific papers

Synthesis and biological activity of 3-substituted isoxazolecarboxamides

A series of novel 3-substituted isoxazolecarboxamides have been prepared. A key step was 1,3-dipolar cycloaddition of nitrile oxides to α,β-unsaturated esters. Some of these compounds exhibited high fungicidal activities against Alternaria alternata, Botrytis cinerea, Rhizoctonia solani, Fusarium culmorum, and Phytophthora cactorum.

Concise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins

The synthesis of a series of new 5-isoxazolpenicillins is described, which were obtained by coupling substituted isoxazoles with 6-APA. Concise large-scale synthesis of 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition using copper(I) as catalyst was also investigated. Representative compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-negative bacteria.

Some Reactions of β-Aroylacrylic Acid Epoxides

β-Aroylacrylic acids (I) on reaction with hydrogen peroxide give α,β-epoxy-β-aroylacrylic acids (II) which on treatment with sodium hydroxide afford a mixture of arylmethyl 1,2-diketone (III) and arylmethyl glycollic acid (IV).The mixture is separated bei