29203-60-9

Basic information

• Product Name: 2,4-DICHLORO-N-HYDROXYBENZENECARBOXIMIDOYL CHLORIDE
• Synonyms: 2,4-DICHLORO-N-HYDROXYBENZENECARBOXIMIDOYL CHLORIDE;BUTTPARK 153\57-27;ALPHA,2,4-TRICHLOROBENZALDOXIME;2,4-DICHLORO-N-HYDROXYBENZIMIDOYL CHLORIDE
• CAS NO: 29203-60-9
• Molecular Formula: C₇H₄Cl₃NO
• Molecular Weight: 224.47
• Mol File: 29203-60-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 93 °C
• Boiling Point: 339.7°Cat760mmHg
• Flash Point: 159.2°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 3.51E-05mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 2,4-DICHLORO-N-HYDROXYBENZENECARBOXIMIDOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-N-HYDROXYBENZENECARBOXIMIDOYL CHLORIDE(29203-60-9)
• EPA Substance Registry System: 2,4-DICHLORO-N-HYDROXYBENZENECARBOXIMIDOYL CHLORIDE(29203-60-9)

Safety Data

• Hazard Codes: C
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 29203-60-9(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-N-hydroxybenzenecarboximidoil chloride is a chemical compound with the molecular formula C7H4Cl2NO2. It is a highly reactive and potent herbicide and plant growth regulator that is widely used in agriculture to control broadleaf weeds and woody plants. The compound primarily functions by disrupting plant hormone balance, leading to uncontrolled growth and eventual death of the targeted plants. Due to its high toxicity and potential environmental impact, its use is strictly regulated and requires proper handling and application methods to minimize risks to human health and the ecosystem.

InChI:InChI=1/C7H4Cl3NO/c8-4-1-2-5(6(9)3-4)7(10)11-12/h1-3,12H

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 56843-28-8 2,4-dichlorobenzaldoxime 

Downstream Products

• 100726-70-3 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester 
• 37737-64-7 3-(2,4-dichloro-phenyl)-4-ethyl-5-phenyl-4,5-dihydro-[1,2,4]oxadiazole 
• 133808-30-7 O-(Z-Phenylalanyl)-2,4-dichlor-benzohydroxamsaeure 
• 139059-92-0 3-(2,4-dichlorophenyl)-6-oxo-8,8-dimethyl-1-oxa-2,7-diazaspiro<4.4>non-2-ene 
• 149009-63-2 <<(2,4-dichlorophenyl)(hydroximino)methyl>thio>acetic acid 
• 54696-53-6 3,4-di-(2,4-dichlorophenyl)furoxan 
• 138535-70-3 3-(2,4-dichlorophenyl)-5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-2-isoxazoline 
• 138535-70-3 (3aR,5S,6S,6aR)-5-[(S)-3-(2,4-Dichloro-phenyl)-4,5-dihydro-isoxazol-5-yl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol 
• 4402-77-1 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester 
• 1312713-56-6 (4-(tert-butyl)phenyl)(3-(2,4-dichlorophenyl)-8-isopropyl-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)methanone 
• 1312713-64-6 1-(8-(3-chlorophenyl)-3-(2,4-dichlorophenyl)-1-oxa-2,7,8-triazaspiro[4.4]non-2-en-7-yl)ethanone 

Relevant articles and documents

Seeking potent anti-tubercular agents: Design, synthesis, anti-tubercular activity and docking study of various ((triazoles/indole)-piperazin-1-yl/1,4-diazepan-1-yl)benzo[d]isoxazole derivatives

A series of thirty eight novel 3-(4-((substituted-1H-1,2,3-triazol-4-yl)methyl)piperazin-1-yl/1,4-diazepan-1-yl)benzo[d]isoxazole and 1-(4-(benzo[d]isoxazol-3-yl)piperazin-1-yl/1,4-diazepan-1-yl)-2-(1H-indol-3-yl)substituted-1-one analogues were synthesised, characterised using various analytical techniques and evaluated for in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain and two 'wild' strains Spec. 210 and Spec. 192. The titled compounds exhibited minimum inhibitory concentration (MIC) ranging from 6.16 to >200 μM. Among the tested compounds, 7i, 7y and 7z exhibited moderate activity (MIC = 24.03-29.19 μM) and 7j exhibited very good anti-tubercular activity (MIC = 6.16 μM). Furthermore, 7i, 7j, 7y and 7z were found to be non-toxic against mouse macrophage cell lines when screened for toxicity. All the synthesised compounds were docked to pantothenate synthetase enzyme site to know deferent binding interactions with the receptor.

COMPOUNDS FOR MODULATING FXR

Provided herein are compounds of Formula (I), a stereoisomer, enantiomer or a pharmaceutically acceptable salt thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

Copper-catalysed synthesis of 3,5-disubstituted isoxazoles enabled by pyridinyl benzimidazol (PBI) as a bidentate N-chelating ligand under mild conditions

In this paper, we introduced pyridinyl benzimidazol (PBI) as an easy-to-handle and bidentate N-chelating ligand that promote clean synthesis of 3,5-disubstituted isoxazoles in the presence of copper acetate as catalyst. This catalytic approach initiates with the hydroxyamination of aldehydes followed by chlorination and then generation of nitrile oxide which subsequently undergoes click-type [3?+?2]-dipolar cycloaddition with alkynes to give isoxazoles. This method provides an alternative green process to construct isoxazole derivatives.