78877-45-9Relevant academic research and scientific papers
An interesting dichotomy in the cyclisation of exocyclic enamines with protected dehydroamino acids leading to different β-turn templates
Berry, Jane M.,Doyle, Paul M.,Young, Douglas W.
, p. 8963 - 8966 (2007/10/03)
Two templates for the preparation of external β-turns have been synthesised. In the course of the synthetic studies an interesting dichotomy was observed in the PCl3 catalysed reaction of exocyclic enamines such as 6 and 14 with protected dehyd
Synthesis of Bicyclic Pyridone and Dihydropyridone Analogues of β-Lactam Antibiotics
Capps, Nigel K.,Davies, Gareth M.,Loakes, David,McCabe, Richard W.,Young, Douglas W.
, p. 3077 - 3086 (2007/10/02)
Condensation of the vinylogous urethanes 2, 26, 28 and 29 with acrylates, haloacrylates and propiolic acid has afforded easy access to bicyclic dihydropyridone and pyridone analogues of cephalosporins, carbapenams, penicillins and bisnorpenicillins.Synthe
Simple and Effective Synthesis of Pyridothiazines
McCabe, Richard W.,Young, Douglas W.,Davies, Gareth M.
, p. 395 - 396 (2007/10/02)
One-step annelation of the 1,3-thiazine derivatives (1, R1 = H) is achieved using substituted acrylic acids under peptide coupling conditions; use of sterically hindered acrylic acids results in an anomalous reaction and the thiazine derivative (1, R1 = R
