78888-67-2

Basic information

• Product Name: Benzamide, N-[4-[1-oxo-2-[[4-(phenylmethyl)-1-piperidinyl]methyl]-2-propenyl]phenyl] -, monohydrochloride
• CAS NO: 78888-67-2
• Molecular Formula: C29H30N2O2.ClH
• Molecular Weight: 475.03
• Mol File: 78888-67-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[4-[1-oxo-2-[[4-(phenylmethyl)-1-piperidinyl]methyl]-2-propenyl]phenyl] -, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[4-[1-oxo-2-[[4-(phenylmethyl)-1-piperidinyl]methyl]-2-propenyl]phenyl] -, monohydrochloride(78888-67-2)
• EPA Substance Registry System: Benzamide, N-[4-[1-oxo-2-[[4-(phenylmethyl)-1-piperidinyl]methyl]-2-propenyl]phenyl] -, monohydrochloride(78888-67-2)

Safety Data

• Hazardous Substances Data: 78888-67-2(Hazardous Substances Data)

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 5411-13-2 N-(4-acetylphenyl)benzamide 
• 23239-75-0 4-benzylpiperidin-1-ium chloride 

Relevant articles and documents

N-substituted alpha-aminoalkylacrylophenones and some related compounds: a new class of spermicidal agents.

The results of a screening program to test the spermicidal effectiveness of several compounds is presented. The program was initiated after N-substituted 3-aminoacrylophenones were found to have unexpected spermicidal activity. The compounds had been synthesized as possible antiinflammatory agents. This result prompted the synthesis and screening of N-substituted alpha-aminomethylacrylophenones, alpha-(2-aminomethyl)acrylophenones and 3-N-substituted-2-methyleneindan-1-ones. The starting materials, substituted acetophenones, for the synthesis of N-substituted alpha-aminomethylacrylophenones were either commercial products or obtained by standard methods. N-substituted amino-butyrophenone was reacted with paraformaldehyde to yield the alpha-(2 aminoethyl)acrylophenones. A series of reactions was undertaken to synthesize 2-methyleneindan-1-ones. The preparation of each is detailed and molecular formulas are provided. Spermicidal activity was assessed by dissolving the compound in physiological saline at different concentrations. 2 drops of rat sperm suspension or human semen were placed on a slide, followed by 2 drops of a compound solution. Control slides of physiological saline were prepared. The contents were mixed for approximately 5 seconds and examined under a phase contrast microscope. The results were considered positive if 100% of the spermatozoa became immotile instantaneously. Several of the compounds showed marked spermicidal activity.