78891-29-9Relevant academic research and scientific papers
Synthesis of the Bacterial Coenzyme Methoxatin
Gainor, James A.,Weinreb, Steven M.
, p. 2833 - 2837 (2007/10/02)
The details of a total synthesis of methoxatin (1), the coenzyme of several bacterial alcohol dehydrogenases, are presented.Methoxatin has been prepared in 13 steps by starting from 2,3-dimethoxytoluene.The successful synthetic strategy for construction of the coenzyme used a Pfitzinger synthesis for preparation of the quinoline dicarboxylic acid portion of 1 and an "umpolung" variation of the Reissert indole synthesis for annulation of the remaining pyrrole ring.
Total Synthesis of Methoxatin, the Coenzyme of Methanol Dehydrogenase and Glucose Dehydrogenase
Gainor, James A.,Weinreb, Steven M.
, p. 4317 - 4319 (2007/10/02)
The first total synthesis of the bacterial coenzyme methoxatin has been successfully completed starting from readily available 2,3-dimethoxytoluene.
