78892-29-2Relevant academic research and scientific papers
IMIDAZOLE DERIVATIVES AS IDO INHIBITORS
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Page/Page column 112, (2011/06/11)
Presently provided are IDO inhibitors of general formulae (VII), (VIII) as shown below and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
Simultaneous deprotection and purification based on ionic resin capture: Application to amide formations and Grignard and Mitsunobu reactions
Meier, Peter,Mueller, Sascha
, p. 2203 - 2207 (2008/03/28)
Products containing Boc- or Tr-protected amines were caught directly out of reaction mixtures by simultaneous cleavage of the protecting group. By releasing the products with ammonia the corresponding free amines were obtained in high yields and purities.
A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds
Turner, Richard M.,Lindell, Stephen D.,Ley, Steven V.
, p. 5739 - 5740 (2007/10/02)
Treatment of N-protected 4-iodoimidazoles 1-3 in CH2Cl2 solution with an etheral solution of ethylmagnesium bromide generates the corresponding imidazol-4-yl anions, which react with carbonyl compounds to give carbinols 4-14 in 60-83percent yield.
