135773-27-2Relevant academic research and scientific papers
Simultaneous deprotection and purification based on ionic resin capture: Application to amide formations and Grignard and Mitsunobu reactions
Meier, Peter,Mueller, Sascha
, p. 2203 - 2207 (2007)
Products containing Boc- or Tr-protected amines were caught directly out of reaction mixtures by simultaneous cleavage of the protecting group. By releasing the products with ammonia the corresponding free amines were obtained in high yields and purities.
Benzopyranone and quinolone inhibitors of ras farnesyl transferase
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, (2008/06/13)
The present invention provides ras farnesyl transferase inhibiting compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds
Turner, Richard M.,Lindell, Stephen D.,Ley, Steven V.
, p. 5739 - 5740 (2007/10/02)
Treatment of N-protected 4-iodoimidazoles 1-3 in CH2Cl2 solution with an etheral solution of ethylmagnesium bromide generates the corresponding imidazol-4-yl anions, which react with carbonyl compounds to give carbinols 4-14 in 60-83percent yield.
