78899-96-4Relevant articles and documents
A General and Simple Synthesis of α-Halo Amides via α,α-Dicyano Epoxides
Pironnec, Marie-Gabrielle Le,Guinamant, Jean-Luc,Robert, Albert,Baudy-Floc'h, Michele
, p. 229 - 232 (2007/10/03)
A one-pot reaction of α,α-dicyano epoxides with amine hydrohalides provides an attractive and general route to α-halo amides.A wide variety of amines (primary alkyl, aryl, amino esters, amino amides) and epoxides (monosubstituted alkyl, aryl: disubstitute
Base-Promoted Reaction of O-Sulfonylated Hydroxamic Acids with Nucleophiles. A New Mehtod for the Synthesis of α-Substituted Amides
Hoffman, Ribert V.,Nayyar, Naresh K.,Chen, Wenting
, p. 5700 - 5707 (2007/10/02)
Treatment of a series of hydroxamic acids 2 with mesyl chloride in the presence of 2 equiv of triethylamine at 0 deg C gives 2-chloroamides 3 in good yields.Use of a single equivalent of triethylamine gives the N-(mesyloxy)amides 1, which are versatile sy
Opening of gem dicyano epoxides with amino hydrohalides: Application to the synthesis of structural analogs of tetramisole and biological evaluation
Jaguelin,Robert,Genetet,Gayral
, p. 313 - 321 (2007/10/02)
α-halogenamides are prepared in a onepot reaction by reacting gem dicyano epoxides with amino hydrohalides. This original reactivity of gem dicyano epoxides is used to prepare substituted [2,1-b]imidazothiazoles which are structural analogs of tetramisole