78979-49-4

Upstream product

• 3411-58-3 L-cystein ethyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 868-59-7 L-cysteine ethyl ester hydrochloride 

Downstream Products

• 78979-56-3 (R)-3-Acetyl-2-(4-nitro-phenyl)-thiazolidine-4-carboxylic acid ethyl ester 
• 642471-92-9 3-[N-(tert-butoxycarbonyl)-L-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione 
• 642471-93-0 3-[N-(tert-butoxycarbonyl)-D-phenylalanyl]amino-3-ethoxycarbonyl-2,3-dihydrothiopheno[2,3-b]naphthalene-4,9-dione 
• 368427-26-3 3-amino-3-(ethoxycarbonyl)-2,3-dihydrothieno[2,3-b]naphtho-4,9-dione 
• 78979-64-3 ethyl 2-(4-nitrophenyl)thiazole-4-carboxylate 

Relevant academic research and scientific papers

Reversible thiazolidine exchange: A new reaction suitable for dynamic combinatorial chemistry

New dynamic combinatorial libraries (DCLs) were generated using the reversible aminothiol exchange reaction of thiazolidines and aromatic aldehydes. The reaction proceeded in aqueous buffered media at pH 4 and room temperature to generate thermodynamically controlled mixtures of heterocycles. The synthesis of an enantiomerically pure thiazolidinyloxazolidine is also reported. The oxazolidine moiety could be exchanged in CH2Cl2 in the presence of catalytic p-TsOH.

Synthesis of Oxazolidines, Thiazolidines, and 5,6,7,8-Tetrahydro-1H,3H-pyrrolooxazole (or thiazole)-1,3-diones from β-Hydroxy- or β-Mercapto-α-amino Acid Esters

2-Aryl-4-(ethoxycarbonyl)oxazolidines and thiazolidines (1) were prepared from the corresponding α-amino acid ethyl esters containing either hydroxyl or mercapto groups in the β position by fusion with some aromatic aldehydes.Dehydrogenation of 1 with N-b