642471-92-9Relevant academic research and scientific papers
New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: Synthesis and biological evaluation as potential antitumoral agents
Gomez-Monterrey, Isabel,Campiglia, Pietro,Grieco, Paolo,Diurno, Maria Vittoria,Bolognese, Adele,La Colla, Paolo,Novellino, Ettore
, p. 3769 - 3775 (2003)
Novel antitumoral agents with quinonic structure were synthesized and evaluated for their in vitro cytotoxic activities. This study examines the cytotoxic activities of several aryl benzo[g]isoquinoline-5,10-dione derivatives and a number of aminoacyl dih
Design, synthesis, and cytotoxic evaluation of acyl derivatives of 3-aminonaphtho[2,3-b ]thiophene-4,9-dione, a quinone-based system
Gomez-Monterrey, Isabel,Campiglia, Pietro,Aquino, Claudio,Bertamino, Alessia,Granata, Ilaria,Carotenuto, Alfonso,Brancaccio, Diego,Stiuso, Paola,Scognamiglio, Ilaria,Rusciano, M. Rosaria,Maione, Angela Serena,Illario, Maddalena,Grieco, Paolo,Maresca, Bruno,Novellino, Ettore
scheme or table, p. 4077 - 4091 (2011/08/05)
A series of 3-acyl derivatives of the dihydronaphtho[2,3-b]thiophen-4,9- dione system were studied with respect to cytotoxicity and topoisomerase II inhibitory activity. These analogues were designed as electron-deficient anthraquinone analogues with pote
Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based α,α-amino esters
Campiglia, Pietro,Aquino, Claudio,Bertamino, Alessia,De Simone, Nicoletta,Sala, Marina,Castellano, Sabrina,Santoriello, Marisabella,Grieco, Paolo,Novellino, Ettore,Gomez-Monterrey, Isabel M.
scheme or table, p. 622 - 627 (2010/05/02)
An unusual and efficient method for the synthesis of new quinone-based amine and its derivatives from the corresponding α,α-amino ester is described. The procedure involves the quinone-based system's oxidative decarboxylation via hydride transfer throughout basic hydrolysis. This synthetic method provides, with good yields, rapid access to new potentially cytotoxic quinones.
