78987-88-9Relevant academic research and scientific papers
Polyfunctional molecules in processes of aromatic nucleophilic substitution 3. Pentaf luoropyridines as scaffolds for synthesis of liquid-phase combinatorial libraries based on S N Ar processes
Litvak,Mainagashev,Bukhanets
, p. 980 - 985 (2008/09/17)
A possibility of using polyfluorinated pyridines as multiply modified molecules, i.e., scaffolds, in processes of aromatic nucleophilic substitution (S N Ar) for the synthesis of liquid-phase combinatorial libraries was studied. The real and "virtual" combinatorial libraries of diaryl ethers were synthesized by the reactions of pentafluoropyridine with phenol and its derivatives. Some criteria for the estimation of the quality of the libraries were formulated. A rational methodology for the preparation of representative combinatorial mixtures on the basis of processes of the S N Ar type in polyfluorinated arenes was proposed. The libraries can be used in highly efficient biological screening of low-molecular-weight regulators of transferase functioning.
ALKALINE METAL FLUORIDES IN GRAPHITE - NEW CATALYSTS IN ORGANIC SYNTHESIS. I. REACTIONS OF POLYFLUOROAROMATIC COMPOUNDS WITH O- AND N-NUCLEOPHILIC AGENTS
Aksenov, V. V.,Vlasov, V. M.,Danilkin, V. I.,Rodionov, P. P.,Shnitko, G. N.
, p. 57 - 73 (2007/10/02)
The paper reports the use of new catalysts - alkaline metal fluorides in graphite of the general formula C8MF, where M=Li, Na, K, Rb or Cs, in the reactions of polyfluoroaromatic compounds with aromatic OH-acids and piperidine.These compounds are shown to have a high activity in the above processes, exceeding that of similar free fluorides of alkaline metals.
INTERACTION OF PENTAFLUOROPYRIDINE WITH 4-NITROPHENOL AND PENTAFLUOROPHENOL IN THE PRESENCE OF POTASSIUM FLUORIDE AND 18-CROWN-6-ETHER
Aksenov, V. V.,Vlasov, V. M.,Yakobson, G. G.
, p. 439 - 458 (2007/10/02)
The reactions of 4-nitro- and pentafluorophenols with C5F5N, 4-ArOC5F4N and 2,4-(ArO)2C5F3N (Ar = 4-NO2C6H4, C6F5) in the presence of KF and catalytic amounts of 18-crown-6-ether at various temperatures have been investigated.The leaving ability of the C6
