78998-93-3Relevant academic research and scientific papers
Construction of bicyclic ring systems via a transannular SmI 2-mediated ketone-olefin cyclization strategy
Molander, Gary A.,Czako, Barbara,Rheam, Michael
, p. 1755 - 1764 (2008/02/01)
The development of novel methods and strategies for the formation of polycyclic ring structures is of utmost importance in organic synthesis. The present study describes the investigation of a transannular cyclization strategy for constructing bicyclic ri
Acid-induced transannular cyclization of 2-methyl- and 10-methyl-5-cyclodecenone
Chu, Yongliang,White, James B.,Duclos, Brian A.
, p. 3815 - 3817 (2007/10/03)
2-Methyl- and 10-methyl-5-cyclodecenone were made by anionic oxy-Cope rearrangement of the corresponding 1,2-divinylcyclohexanols, and their transannular cyclizations were induced using trifluoroacetic acid. In each case, a single diastereomer of a trans fused bicyclo[4.4.0]decan-1-ol with an equatorial methyl group was isolated. The methyl substituent at C2 or C10 of the 5-cyclodecenone did not alter the regio- and stereochemistry previously observed for the parent ring system, (E)-5-cyclodecenone. The relative stereochemistry of the products was determined spectroscopically from J-value analysis and NOE.
A FACILE PREPARATION OF DIFFERENTIATED 1,2-DIVINYLCYCLOALKANOLS
Holt, Dennis A.
, p. 2243 - 2246 (2007/10/02)
A method is described which permits one-step conversion of 2-chlorocycloalkanones to differentiated 1,2-divinylcycloalkanols, 2-vinylcycloalkanones, or 2-vinylcycloalkanols.
