79010-52-9Relevant academic research and scientific papers
SYNTHESIS OF SOME 6-ARYLAMINO-3-AMINO-1,2,4,5-DITHIADIAZINES
Singh, Anirudh P.,Singh, Rajendra,Verma, Vinay Kumar
, p. 2373 - 2380 (2007/10/02)
The synthesis of some new 6-arylamino-3-amino-1,2,4,5-dithiadiazines (IIIa-e) has been achieved by following a novel route.
Oxidation and Eliminative Cyclisation of S-Alkylisodithiobiureas
Indukumari, P. V.,Joshua, C. P.,Rajan, V. P.
, p. 384 - 387 (2007/10/02)
Isothiocyanates condense with S-alkylisothiosemicarbazides to yield S-alkylisodithiobiureas.These undergo cyclisation to give 3-amino-5-mercapto-4-substituted-1,2,4-triazoles with the elimination of alkyl mercaptan on heating under neutral conditions, whereas under acidic conditions, by elimination of ammonia 5-alkylmercapto-2-substituted amino-1,3,4-thiadiazoles are formed.Condensation of isothiocyanates with thiosemicarbazides in the presence of alkali affords 1-substituted dithiobiureas.Alkylation of these dithiobiureas with alkyl halides results in the formation of 5-alkylmercapto-2-substituted-amino-1,3,4-thiadiazoles, any intermediateproduct not being isolable.On the other hand, oxidation of 1-substituted dithiobiureas with either hydrogen peroxide or iodine furnishes 2-amino-5-substituted-amino-1,3,4-thiadiazoles.
