79014-69-0Relevant academic research and scientific papers
Synthesis of phosphinic and phosphonic analogs of aromatic amino acids
Belyankin,Khomutov,Zhukov,Kartasheva,Khomutov
, p. 133 - 136 (2007/10/03)
The reaction of aryl and aralkyl aldoximes with hypophosphorous acid resulted in aminophosphinic acids, which were oxidized into the corresponding aminophosphonic acids.
Synthesis of α-substituted α-aminophosphinic and α-aminophosphonic acids
Osipova,Belyankin,Khomutov,Zhukov,Khurs,Khomutov
, p. 2588 - 2591 (2007/10/03)
The reaction of ketoximes with hypophosphorous acid resulted in previously unknown α-substituted-α-aminophosphimc acids, which were oxidized into the corresponding α-substituted-α-aminophosphonic acids.
The Synthesis of 1-Aminoalkylphosphonic Acids. A Revised Mechanism of the Reaction of Phosphorus Trichloride, Amides and Aldehydes or Ketones in Acetic Acid (Oleksyszyn Reaction)
Soroka, Miroslaw
, p. 331 - 334 (2007/10/02)
The mechanism of the amidoalkylation of trivalent phosphorus compounds in acetic acid has been reinvestigated.Evidence is presented that 1-(acylamino)alkyl acetates 5 and not N,N'-alkylidenebisamides 2 are the intermediates in this reaction.Supporting literature analogies are discussed.This paper also describes a convenient procedure for the preparation of crude (acylamino)alkyl alkanoates 5, which are excellent amidoalkylating agents.The usefulness of these reagents is demonstrated by a simple two-step "one pot" synthesis of 1-aminoalkylphosphinic acids 1.
