79020-64-7Relevant academic research and scientific papers
Synthesis of (±)-5,6,7-trinor-4,8-inter-m-phenylene PGI2
Ohno, Kiyotaka,Nishiyama, Hisao,Nagase, Hiroshi,Matsumoto, Kazuhisa,Ishikawa, Mamoru
, p. 4489 - 4492 (1990)
A stable and potent analog of prostacyclin, the titled compound, and its derivative were synthesized from readily available 1,4-dibromocyclopentene via 5-(4-tetrahydropyranyloxybutyl)cyclopenta[b]benzofuran 7.
Synthesis of 5,6,7-trinor-4,8-inter-m-phenylene PGI2 and Beraprost
Wakita, Hisanori,Matsumoto, Kazuhisa,Yoshiwara, Hideo,Hosono, Yutaka,Hayashi, Ryoji,Nishiyama, Hisao,Nagase, Hiroshi
, p. 2449 - 2474 (2007/10/03)
We have disclosed a new class of stable PGI2 analogue, 5,6,7-trinor- 4,8-inter-m-phenylene PGI2 which has a phenyl ether moiety instead of enol- ether skeleton in PGI2. The m-phenylene PGI2 and its derivative (Betaprost) were synthesized via dihydrocyclopenta[b]benzofuran derivatives as key intermediates by ortho-selective metal-halogen exchange reaction with Grignard reagents and subsequent copper-catalyzed cyclization. The ω-side chains were introduced by stereoselective epoxide formation or Prins reaction.
