790239-55-3

Upstream product

• 100-39-0 benzyl bromide 
• 136818-52-5 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid methyl ester 
• 160857-78-3 (Z)-2-azido-3-(1,3-benzodioxol-5-yl)acrylic acid methyl ester 
• 120-57-0 piperonal 
• 136818-51-4 methyl 2-azido-3-benzo[1,3]dioxol-5-ylacrylate 

Downstream Products

• 790239-65-5 5-benzyl-5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid 
• 790239-15-5 1-(5-benzyl-5H-[1,3]dioxolo[4,5-f]indol-6-yl)ethanone 
• 1584224-40-7 C₁₇H₁₅NO₃ 
• 1584224-43-0 C₁₇H₁₃NO₃ 
• 1584224-45-2 C₂₄H₂₀N₂O₄S 
• 1584224-46-3 C₂₄H₂₂N₂O₄S 
• 1529806-97-0 5-benzyl-4'-methyl-1',7-ditosyl-1',5,5',6,7,8-hexahydro-spiro[[1,3]dioxolo[4,5-f]pyrido[3,4-b]indole-9,2'-pyrrole] 
• 1529806-77-6 N-((5-benzyl-5H-[1,3]dioxolo[4,5-f]indol-6-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosyl-aziridin-2-yl)prop-2-ynyl)benzenesulfonamide 

Relevant academic research and scientific papers

Gold(I)-catalyzed rearrangement of alkynylaziridine indoles for the synthesis of spiro-tetrahydro-β-carbolines

Functionalized spiro-tetrahydro-β-carbolines were formed by an efficient gold(I)-catalyzed rearrangement reaction of alkynylaziridine indoles. The reaction involved a Friedel-Crafts type intramolecular reaction of alkynylaziridine indoles, following by hydroamination of aminoallene intermediate.

Design and synthesis of novel indole β-diketo acid derivatives as HIV-1 integrase inhibitors

Diketo acids such as S-1360 (1A) and L-731,988 (2) are potent and selective inhibitors of HIV-1 integrase (IN). A plethora of diketo acid-containing compounds have been claimed in patent literature without disclosing much biological activities and synthetic details (reviewed in Neamati, N. Exp. Opin. Ther. Pat. 2002, 12, 709-724). To establish a coherent structure - activity relationship among the substituted indole nucleus bearing a β-diketo acid moiety, a series of substituted indole-β-diketo acids (4a-f and 5a-e) were synthesized. All compounds tested showed anti-IN activity at low micromolar concentrations with varied selectivity against the strand transfer process. Three compounds, the indole-3-β-diketo acids 5a and 5c, and the parent ester 9c, have shown an antiviral activity in cell-based assays. We further confirmed a keto-enolic structure in the 2,3-position of the diketo acid moiety of a representative compound (4c) using NMR and X-ray crystallographic analysis. Using this structure as a lead for all of our computational studies, we found that the title compounds extensively interact with the essential amino acids on the active site of IN.