790248-16-7Relevant academic research and scientific papers
Cp2ZrMeCl: A Reagent for Asymmetric Methyl Addition
Garrec, Kilian,Fletcher, Stephen P.
supporting information, p. 3814 - 3817 (2016/08/16)
The use of Cp2ZrMeCl is described as a source of nucleophilic methyl in asymmetric catalysis. This easily prepared reagent is bench stable, weighable in air, and generally useful in highly enantioselective copper-catalyzed addition reactions at room temperature. Methyl is successfully (generally >90% ee) added in 1,4-additions to cyclic and acyclic α,β-unsaturated ketones to provide tertiary and quaternary centers. Examples of catalyst controlled diastereoselective 1,6-addition and dynamic kinetic asymmetric allylic alkylation reactions are also reported. The reagent is used in the catalytic asymmetric synthesis of naturally occurring fragrance (R)-(-)-muscone (82% yield, 91% ee).
Copper-catalyzed enantioselective conjugate addition of Grignard reagents to acyclic enones
Lopez, Fernando,Harutyunyan, Syuzanna R.,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 12784 - 12785 (2007/10/03)
A highly enantioselective Cu-catalyzed addition of Grignard reagents to acyclic aliphatic enones is described. In the presence of 5 mol % of CuBr·SMe2 and 6 mol % of JosiPhos diphosphine aliphatic enones react with Grignard reagents to provide β-substituted linear ketones with high yields, regio-, and enantioselectivities. Copyright
Specific features of thermal degradation of polypropylene in the presence of magnesium hydroxide
Koverzanova,Usachev,Shilkina,Lomakin,Gumargalieva,Zaikov
, p. 445 - 448 (2007/10/03)
Specific features of thermal oxidative degradation of polypropylene and its composite with Mg(OH)2 were studied by pyrolytic gas chromatography-mass spectrometry and thermal gravimetric analysis.
Copper-catalysed asymmetric conjugate addition of organometallic reagents to linear enones using thiourethane ligands
Bennett, Simon M.W.,Brown, Stephen M.,Muxworthy, James P.,Woodward, Simon
, p. 1767 - 1770 (2007/10/03)
In the presence of chiral thiourethane ligands [Cu(MeCN)4]BF4 forms active catalysts for the conjugate addition of MeMgBr, ZnEt2 and AlR3 (R = Me, Et) to non-3-en-2-one, hept-3-en-2-one, and 5-methylhex-3-en-2-one. Enantioselectivities of up to 51% are realised for these difficult substrates; for cyclohex-2-enone an e.e. of 42% is attained.
