79025-26-6Relevant academic research and scientific papers
QUINAZOLINONE COMPOUNDS
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Paragraph 0126, (2020/09/12)
New quinazolinone compounds are disclosed, as well as pharmaceutical compositions containing quinazolinones and methods for the treatment of diseases and conditions associated with mitochondrial dysfunction.
A NOVEL SMALL MOLECULE COMPOUND
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Paragraph 0078; 0079, (2019/04/11)
The present invention relates to compositions and methods for the treatment of cancer and other diseases associated with mitochondrial dysfunction, including but not limited to, neurodegenerative disease, brain injuries, and certain non-neurological disorders, using a novel compound, 6-chloro-3-(2,4-dichloro-5-methoxyphenyl)-2-mercapto-7- methoxyquinazolin-4(3H)-one, and derivatives thereof.
Design of photonic liquid crystal materials: Synthesis and evaluation of new chiral thioindigo dopants designed to photomodulate the spontaneous polarization of ferroelectric liquid crystals
Dinescu, Liviu,Maly, Kenneth E.,Lemieux, Robert P.
, p. 1679 - 1686 (2007/10/03)
Irradiation of a ferroelectric S(c)* liquid crystal phase induced by the photochromic dopants (R,R)-6,6'-bis(2-octyloxy)-5,5'-dinitrothioindigo and (R,R)-5,5'-dichloro-6,6'-bis(2-octyloxy)thioindigo at λ=514 and 532 nm, respectively, causes an increase in spontaneous polarization (P(s)) by a factor ranging from 1.4 to 4.0. This increase in P(s) is achieved without concomitant destabilization of the S(c)* phase, and is consistent with an increase in transverse dipole moment of the thioindigo core as a result of trans-cis photoisomerization. The contribution of the thioindigo core towards P(s) is achieved through stereo-polar coupling with the chiral side-chains, which is enhanced by the presence of the nitro and chloro substituents.
Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
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, (2008/06/13)
2,4-Diaminoquinazolines of the formula STR1 wherein Y1 is hydrogen or chloro, Y2 is OR, Y3 is hydrogen or OR such that when Y1 is hydrogen, Y3 is OR and when Y1 is chloro, Y3 is hydrogen or OR, and the pharmaceutically acceptable salts thereof; R represents an alkyl group having from one to three carbon atoms; taken separately, R1 and R2 are each hydrogen, alkyl having from one to five carbon atoms, cycloalkyl having from three to eight carbon atoms, alkenyl or alkynyl each having from three to five carbon atoms or hydroxy substituted alkyl having from two to five carbon atoms, when taken together with the nitrogen atom to which they are attached R1 and R2 form a substituted or unsubstituted heterocyclic group optionally containing an atom of oxygen, sulfur or a second atom of nitrogen as a ring member; their use as antihypertensive agents, pharmaceutical compositions containing them and intermediates for their production.
