245743-64-0Relevant articles and documents
NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS
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Paragraph 0291, (2019/01/21)
The present invention discloses compounds according to Formula (I) Wherein R1, R2, L, A1, A2, A3, Cy and the subscript n are as defined herein. The present invention relates to antagonists compounds of sphingosine 1-phosphate (SIP) receptor, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, inflammatory diseases, respiratory diseases, autoimmune diseases, metabolic diseases, cardiovascular diseases, and/or proliferative diseases by administering the compound of the invention.
Design of photonic liquid crystal materials: Synthesis and evaluation of new chiral thioindigo dopants designed to photomodulate the spontaneous polarization of ferroelectric liquid crystals
Dinescu, Liviu,Maly, Kenneth E.,Lemieux, Robert P.
, p. 1679 - 1686 (2007/10/03)
Irradiation of a ferroelectric S(c)* liquid crystal phase induced by the photochromic dopants (R,R)-6,6'-bis(2-octyloxy)-5,5'-dinitrothioindigo and (R,R)-5,5'-dichloro-6,6'-bis(2-octyloxy)thioindigo at λ=514 and 532 nm, respectively, causes an increase in spontaneous polarization (P(s)) by a factor ranging from 1.4 to 4.0. This increase in P(s) is achieved without concomitant destabilization of the S(c)* phase, and is consistent with an increase in transverse dipole moment of the thioindigo core as a result of trans-cis photoisomerization. The contribution of the thioindigo core towards P(s) is achieved through stereo-polar coupling with the chiral side-chains, which is enhanced by the presence of the nitro and chloro substituents.