790297-80-2Relevant academic research and scientific papers
PHOSPHODIESTERASE 4 INHIBITORS
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Page/Page column 141; 142, (2008/06/13)
Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula (I) wherein R1, R2, and R3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and use for treating cognition impairment memory impairment, psychosis, schizophrenia, depression, allergic or inflammatory disease, chronic obstructive pulmonary disease, neurodegeneration, stroke, Alzheimer’s disease, multiple sclerosis.
PHOSPHODIESTERASE 4 INHIBITORS
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Page 135-136, (2010/02/09)
Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDR4, inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula (I); wherein R1, R2, and R3 are as defined herein.
