79053-53-5Relevant academic research and scientific papers
1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
-
, (2008/06/13)
Compounds of the formula STR1 wherein R1, R2 and R3 are the same or different and are hydrogen, C1 to C6 alkyl, C6 to C14 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety and R4 is selected from the group having the formula STR2 where R is C1 to C8 alkyl, C1 to C8 alkoxy, halo, cyano, AlkNHC(O)-- or AlkC(O)NH-- and R' is Alk NHC(O) or Alk C(O)NH where Alk is C1 to C6 alkyl or the group 2-(endobicyclo[3.1.0]hexyl)ethyl. Methods for preparing the compounds are disclosed. The compounds are useful for the treatment of hypertension and cardiac disorders.
