79054-43-6

Basic information

• Product Name: [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester
• Synonyms: [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester
• CAS NO: 79054-43-6
• Molecular Weight: 328.305
• Mol File: 79054-43-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester(79054-43-6)
• EPA Substance Registry System: [(E)-1-Dimethylamino-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester(79054-43-6)

Safety Data

• Hazardous Substances Data: 79054-43-6(Hazardous Substances Data)

Upstream product

• 1006713-83-2 diethyl trimethylsilyl-N,N-dimethylaminomethylphosphonate 
• 555-16-8 4-nitrobenzaldehdye 
• 18855-52-2 tetraethyl dimethylaminomethylenediphosphonate 

Downstream Products

• 104-03-0 4-nitrobenzeneacetic acid 
• 79054-54-9 [(E)-1-Hydroxy-2-(4-nitro-phenyl)-vinyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Development of a one-pot method for the homologation of aldehydes to carboxylic acids

A highly efficient method is described for the one-carbon homologation of aldehydes to carboxylic acid derivatives employing the reaction of a 1,1-bis-dimethylphosphonate derivative with the aldehyde and controlled acid hydrolysis of the derived α-phosphonoenamine intermediate.

α-SUBSTITUIERTE PHOSPHONATE-36 α-PHOSPHONOENAMINE UND ACYLPHOSPHONATE DURCH HORNER-OLEFINIERUNG

Phosphonoenamines are formed by Horner-Olefination of N-substituted aminomethane-bis-phosphonic acid esters.These exist, depending on N-substitution, carbonyl compound, and condition of the reaction as pure E- or Z-isomeres resp. as E,Z-mixture.The stereochemistry unambiguously could be derived from the 1H- resp. 13C-NMR-spectra.Mild hydrolysis of the phosphonoenamines yields acylphosphonates; 31P-NMR-data shows, that these exist as a mixture of keto-enol-form.The enol-form of this products could be isolated in crystalline form.Phenylacetylphosphonate, unambiguously synthesized from phenylacetylchloride and triethylphosphite also exist as a mixture of the keto-enol-form.