79054-49-2Relevant academic research and scientific papers
α-SUBSTITUIERTE PHOSPHONATE-36 α-PHOSPHONOENAMINE UND ACYLPHOSPHONATE DURCH HORNER-OLEFINIERUNG
Costisella, B.,Keitel, I.,Gross, H.
, p. 1227 - 1232 (2007/10/02)
Phosphonoenamines are formed by Horner-Olefination of N-substituted aminomethane-bis-phosphonic acid esters.These exist, depending on N-substitution, carbonyl compound, and condition of the reaction as pure E- or Z-isomeres resp. as E,Z-mixture.The stereochemistry unambiguously could be derived from the 1H- resp. 13C-NMR-spectra.Mild hydrolysis of the phosphonoenamines yields acylphosphonates; 31P-NMR-data shows, that these exist as a mixture of keto-enol-form.The enol-form of this products could be isolated in crystalline form.Phenylacetylphosphonate, unambiguously synthesized from phenylacetylchloride and triethylphosphite also exist as a mixture of the keto-enol-form.
