79055-59-7

Usage

Uses

Used in Pharmaceutical Industry:
2-bromo-6-methylpyridin-4-amine is used as a building block for the synthesis of pharmaceuticals, leveraging its unique structure to create compounds with potential therapeutic applications. Its role in the development of new drugs is crucial, as it can be incorporated into molecules that target specific biological pathways or receptors.
Used in Agrochemical Industry:
In the agrochemical sector, 2-bromo-6-methylpyridin-4-amine is utilized as a key intermediate in the synthesis of pesticides and other crop protection agents. Its chemical properties allow for the creation of compounds that can effectively manage pests and diseases in agriculture, thereby enhancing crop yields and quality.
Used in Organic Chemistry Research:
2-bromo-6-methylpyridin-4-amine also serves as an important reagent in organic chemistry. It is employed in various research applications to explore new synthetic pathways, develop novel chemical reactions, and understand the fundamental principles of organic transformations.
Used in Medicinal Chemistry:
As a component in medicinal chemistry, 2-bromo-6-methylpyridin-4-amine is used to design and synthesize new pharmaceutical agents. Its presence in a molecule can influence the pharmacokinetics and pharmacodynamics of drug candidates, making it a versatile building block for drug discovery and development.
Used in Agricultural Chemistry:
In agricultural chemistry, 2-bromo-6-methylpyridin-4-amine is applied in the development of new agrochemicals, including herbicides, insecticides, and fungicides. Its unique structural features enable the creation of compounds that can address specific agricultural challenges, such as resistance in pests or diseases.

Upstream product

• 79055-52-0 2,4-dibromo-6-methylpyridine 
• 60323-99-1 2-bromo-6-methyl-4-nitro-pyridine-1-oxide 
• 5315-25-3 2-bromo-6-methylpyridine 
• 91668-84-7 2-bromo-6-methylpyridine N-oxide 

Downstream Products

• 524717-70-2 2-(3,4-dihydro-1H-isoquinolin-2-yl)-6-methyl-pyridin-4-yl-amine 
• 521917-30-6 2-(7-Chloro-3,4-dihydro-naphthalen-2-yl)-6-methyl-pyridin-4-yl-amine fumarate 
• 99233-21-3 (4-amino-6-methylpyridin-2-yl)methanol 
• 614752-47-5 4-fluoro-6-methyl-2-pyridinecarboxaldehyde 
• 524717-76-8 N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-6-methyl-pyridin-4-yl]-oxalamic acid ethyl ester 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

Optimisation of affinity, chemical stability, metabolic stability and solubility led from a chemically labile HTS hit 1 to mGlu5 receptor antagonists (24-26) with high affinity for the allosteric MPEP binding site, improved microsomal metabolic stability and anxiolytic-like activity in vivo as assessed by the Vogel conflict drinking test.

Conjugated aromatic compounds with a pyridine substituent

The present invention relates to compounds of formulae The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases related to this receptor.

4-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

A series of 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and analogous quinolines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. 2-Hydroxyalkylamino substitution combines high affinity with selectivity (vs α1 and M1 receptors) and activity in vivo.