790627-88-2Relevant academic research and scientific papers
Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs
Flentge, Charles A.,Randolph, John T.,Huang, Peggy P.,Klein, Larry L.,Marsh, Kennan C.,Harlan, John E.,Kempf, Dale J.
supporting information; experimental part, p. 5444 - 5448 (2010/05/02)
The HIV protease inhibitor ritonavir (RTV) is also a potent inhibitor of the metabolizing enzyme cytochrome P450 3A (CYP3A) and is clinically useful in HIV therapy in its ability to enhance human plasma levels of other HIV protease inhibitors (PIs). A nov
Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis
Ye, Weiping,Leow, Dasheng,Goh, Serena Li Min,Tan, Chin-Tong,Chian, Chee-Hoe,Tan, Choon-Hong
, p. 1007 - 1010 (2007/10/03)
A series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only thr
Synthesis of C2-symmetric (S,S)-1,4-dibenzyl-DTPA and 1,4-meso-dibenzyl-DTPA via chiral diamines
Sajiki, Hironao,Ong, Karen Y.
, p. 14507 - 14514 (2007/10/03)
Novel routes to C2-symmetric (S,S)-1,4-dibenzyl-DTPA and 1,4-meso-dibenzyl-DTPA are described. The methodology utilizes readily available starting materials.
