790658-58-1 Usage
General Description
"(3R,4R)-N-Cbz-3,4-difluoropyrrolidine" is a chemical compound that belongs to the group of pyrrolidines, which are organic compounds with a five-membered ring structure containing four carbon atoms and one nitrogen atom. The compound is specifically a 3,4-difluoropyrrolidine derivative, meaning that it contains two fluorine atoms attached to the third and fourth positions of the pyrrolidine ring. The presence of a Cbz (benzyloxycarbonyl) group indicates that the compound has a benzyloxycarbonyl functional group attached to the nitrogen atom. The stereochemical designation (3R,4R) indicates the configuration of the compound, with the R referring to the orientation of the substituents on the third and fourth carbon atoms of the pyrrolidine ring. "(3R,4R)-N-Cbz-3,4-difluoropyrrolidine" may have applications in organic synthesis and medicinal chemistry due to its unique structure and potential reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 790658-58-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,0,6,5 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 790658-58:
(8*7)+(7*9)+(6*0)+(5*6)+(4*5)+(3*8)+(2*5)+(1*8)=211
211 % 10 = 1
So 790658-58-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H13F2NO2/c13-10-6-15(7-11(10)14)12(16)17-8-9-4-2-1-3-5-9/h1-5,10-11H,6-8H2/t10-,11-/m1/s1
790658-58-1Relevant articles and documents
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors
Caldwell, Charles G.,Chen, Ping,He, Jiafang,Parmee, Emma R.,Leiting, Barbara,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Eiermann, George J.,Petrov, Aleksandr,He, Huaibing,Lyons, Kathryn A.,Thornberry, Nancy A.,Weber, Ann E.
, p. 1265 - 1268 (2007/10/03)
Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good pharmacokinetic properties and was orally active in an oral glucose tolerance test in lean mice.
