863396-77-4

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry:
(3R,4R)-3,4-Difluoro-pyrrolidine serves as a crucial building block in the synthesis of an array of pharmaceuticals and bioactive molecules. Its unique structure and fluorinated characteristics contribute to enhancing the properties of the resulting compounds, making it an essential component in drug discovery and development processes.
Used in Agrochemical Industry:
In the agrochemical sector, (3R,4R)-3,4-Difluoro-pyrrolidine holds potential for the development of innovative pesticides and herbicides. Its incorporation into these products is aimed at improving their efficacy and safety profiles, thereby contributing to more effective and environmentally friendly agricultural solutions.

InChI:InChI=1/C4H7F2N/c5-3-1-7-2-4(3)6/h3-4,7H,1-2H2/t3-,4-/m1/s1

Upstream product

• 869488-97-1 (3R,4S)-rel-3,4-difluoropyrrolidine-1-carboxylic acid benzyl ester 
• 790658-58-1 (3R,4R)-3,4-Difluoro-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Therapeutic compounds

The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R1, R2, R3, HET, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors

Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good pharmacokinetic properties and was orally active in an oral glucose tolerance test in lean mice.