790663-15-9Relevant academic research and scientific papers
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists
Hale, Jeffrey J.,Doherty, George,Toth, Leslie,Mills, Sander G.,Hajdu, Richard,Keohane, Carol Ann,Rosenbach, Mark,Milligan, James,Shei, Gan-Ju,Chrebet, Gary,Bergstrom, James,Card, Deborah,Forrest, Michael,Sun, Shu-Yu,West, Sarah,Xie, Huijuan,Nomura, Naomi,Rosen, Hugh,Mandala, Suzanne
, p. 3501 - 3505 (2007/10/03)
Structurally modified 3-(N-benzylamino)propylphosphonic acid S1P receptor agonists that maintain affinity for S1P1, and have decreased affinity for S1P3 are efficacious, but exhibit decreased acute cardiovascular toxicity in rodents than do nonselective agonists.
