79069-15-1

Basic information

• Product Name: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol
• Synonyms: BOC-O-BENZYL-D-SERINOL;BOC-O-BENZYL-L-SERINOL;BOC-D-SER(BZL)-OL;BOC-D-SERINOL(BZL);BOC-(S)-2-AMINO-3-PHENYLMETHOXY-1-PROPANOL;BOC-(R)-2-AMINO-3-PHENYLMETHOXY-1-PROPANOL;BOC-SERINOL(BZL);BOC-SER(BZL)-OL
• CAS NO: 79069-15-1
• Molecular Formula: C₁₅H₂₃NO₄
• Molecular Weight: 281.35
• Product Categories: Amino Acids;Amino Alcohols;Boc-Amino acid series
• Mol File: 79069-15-1.mol
• Article Data: 44

Chemical Properties

• Melting Point: 66-69 °C(lit.)
• Boiling Point: 443.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.105
• Storage Temp.: Store at 0-5°C
• PKA: 11.58±0.46(Predicted)
• CAS DataBase Reference: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol(79069-15-1)
• EPA Substance Registry System: N-Boc-(S)-2-amino-3-benzyloxy-1-propanol(79069-15-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 79069-15-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

Upstream product

• 235744-90-8 [1-benzyloxymethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-carbamic acid tert-butyl ester 
• 80963-10-6 methyl O-benzyl-N-(tert-butoxycarbonyl)-L-serinate 
• 66866-45-3 C₂₀H₂₉NO₇ 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 4726-96-9 O-Benzyl-L-serine 
• 543-27-1 isobutyl chloroformate 
• 47173-80-8 N-Boc-D-serine(Bzl)-OH 
• 108149-63-9 4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 100-39-0 benzyl bromide 
• 1339950-10-5 (R)-tert-butyl 4-((benzyloxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 59524-02-6 N-tert-butoxycarbonyl-L-serine benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 10433-52-0 O-benzyl-D-serine 
• 116611-63-3 methyl N-(tert-butoxycarbonyl)-O-(tetrahydro-2H-pyran-2-yl)-L-serinate 

Downstream Products

• 179472-05-0 Isobutyric acid (S)-3-benzyloxy-2-tert-butoxycarbonylamino-propyl ester 
• 179472-07-2 Isobutyric acid (R)-3-benzyloxy-2-tert-butoxycarbonylamino-propyl ester 
• 552331-47-2 (1S)-[1-benzyloxymethyl-2-(5-bromo-pyridin-3-yloxy)-ethyl]-carbamic acid tert-butyl ester 
• 651031-30-0 (3S,5S)-3,5-bis(benzyloxymethyl)morpholine 
• 651031-14-0 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-propane-1,2-diol 
• 651031-28-6 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)propan-2-ol 
• 651031-18-4 (3S,5R)-3-(benzyloxymethyl)-5-(tert-butyldiphenylsilyloxymethyl)morpholine 
• 651031-29-7 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2R)-1-(benzyloxy)-2-(methanesulfonyl)propane 
• 651031-16-2 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2S)-1-(tert-butyldiphenylsilyloxy)propan-2-ol 
• 651031-17-3 3-[(2S)-2-(tert-butoxycarbonylamino)-3-(benzyloxy)propanoxy]-(2S)-1-(tert-butyldiphenylsilyloxy)-2-(methanesulfonyloxy)propane 
• 179472-13-0 2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propan-1-ol 
• 179472-14-1 1-O-isobutyryl-2-[(tert-butyloxycarbonyl)amino]-3-[N₃-benzoyl(thymin-1-yl)]-L-propanol 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 108149-64-0 (S)-(-)-α-methoxy-α-(trifluoromethyl)phenylacetic acid (4R)-2,2-dimethyl-3-[(1,1-dimethylethoxy)carbonyl]-4-hydroxymethyloxazolidine ester 

Relevant articles and documents

Iterative Synthesis of Stereo- and Sequence-Defined Polymers via Acid-Orthogonal Deprotection Chemistry

Absolute control over polymer stereo- and sequence structure is highly challenging in polymer chemistry. Here, an acid-orthogonal deprotection strategy is proposed for the iterative synthesis of a family of unimolecular polymers starting with enantiopure

Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production

The piperazine heterocycle is broadly exploited in FDA-approved drugs and biologically active compounds, but its chemical diversity is usually limited to ring nitrogen substitutions, leaving the four carbon atoms underutilized. Using an efficient six-step synthesis, chiral amino acids were transformed into 3-substituted piperazine-2-acetic acid esters as diastereomeric mixtures whose cis and trans products (dr 0.56 a? 2.2:1, respectively) could be chromatographically separated. From five amino acids (both antipodes) was obtained a complete matrix of 20 monoprotected chiral 2,3-disubstituted piperazines, each as a single absolute stereoisomer, all but one in multigram quantities. In keeping with our overall purpose of constructing more Csp3-enriched compound libraries for drug discovery, these diverse and versatile piperazines can be functionalized on either nitrogen atom, allowing them to be used as scaffolds for parallel library synthesis and as intermediates for the production of novel piperazine compounds.

LPA5 RECEPTOR AGONIST

PROBLEM TO BE SOLVED: To provide a drug containing as an active ingredient a compound having agonist activity for an LPA5 receptor in disease caused by the LPA5 receptor. SOLUTION: A compound represented by general formula (I) in the figure, where all symbols refer to the same as those described in the specification, or a pharmaceutically acceptable salt thereof is useful as a drug component having agonist activity for an LPA5 receptor in prevention and/or treatment of disease caused by the LPA5 receptor, e.g., digestive system disease, immune system disease or cancer. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT