79080-35-6

Upstream product

• 10447-93-5 1,2-dimethylimidazole 
• 143-33-9 sodium cyanide 
• 54384-71-3 3-cyano-1,5-dimethylpyrazole 
• 79080-37-8 2-cyano-1,5-dimethylimidazole 

Relevant academic research and scientific papers

Anodic Cyanation of 1-Methylimidazoles

The electrooxidation of several 1-methylimidazoles was performed in MeOH that contains NaCN at a platinum anode in a divided cell.Replacement of an aromatic hydrogen by a cyano group occurred.With 1,2,4,5-tetramethylimidazole, the 2,5-addition of cyano groups to the imidazole ring was achieved, and besides side-chain substitution occurred concurrently.

Competing Pathways in the Phototransposition of Pyrazoles

Cyano-substituted pyrazoles transpose photochemically into imidazoles by two concurrent paths: (a) 1,5-interchange, probably by 2,5-bonding to a diazabicyclopentene which isomerises by nitrogen 'walk' before rearomatisation, and (b) 2,3-interchange, probably via an intermediate azirine; in sharp contrast, 1,5-dimethyl-3-trifluoromethylpyrazole phototransposes exclusively by the former path.