79080-37-8Relevant academic research and scientific papers
COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND F1BROTIC DISEASE
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Paragraph 00652, (2020/07/14)
Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a method for assaying such compositions.
Anodic Cyanation of 1-Methylimidazoles
Yoshida, Kunihisa,Kitabayashi, Hirohito
, p. 3693 - 3696 (2007/10/02)
The electrooxidation of several 1-methylimidazoles was performed in MeOH that contains NaCN at a platinum anode in a divided cell.Replacement of an aromatic hydrogen by a cyano group occurred.With 1,2,4,5-tetramethylimidazole, the 2,5-addition of cyano groups to the imidazole ring was achieved, and besides side-chain substitution occurred concurrently.
Competing Pathways in the Phototransposition of Pyrazoles
Barltrop, John A.,Day, A. Colin,Mack, Arthur G.,Shahrisa, Aziz,Wakamatsu, Shigeru
, p. 604 - 606 (2007/10/02)
Cyano-substituted pyrazoles transpose photochemically into imidazoles by two concurrent paths: (a) 1,5-interchange, probably by 2,5-bonding to a diazabicyclopentene which isomerises by nitrogen 'walk' before rearomatisation, and (b) 2,3-interchange, probably via an intermediate azirine; in sharp contrast, 1,5-dimethyl-3-trifluoromethylpyrazole phototransposes exclusively by the former path.
