79080-39-0

Usage

Uses

Used in Pharmaceutical Industry:
1-methyl-1h-pyrazole-3-carbonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its potential bioactivity and ability to contribute to the development of diverse pharmacological agents. Its unique structure allows for the creation of new drug candidates with potential therapeutic benefits.
Used in Agricultural Chemical Industry:
In the agricultural sector, 1-methyl-1h-pyrazole-3-carbonitrile serves as an intermediate in the production of agricultural chemicals, leveraging its chemical properties to enhance the effectiveness of these products in crop protection and other applications.
Used in Organic Synthesis:
1-methyl-1h-pyrazole-3-carbonitrile is utilized as a building block in organic synthesis, particularly for the creation of complex organic compounds. Its nitrile group plays a crucial role in the formation of various organic molecules, expanding the scope of chemical research and development.
Used as a Corrosion Inhibitor in Metal Alloy Industry:
1-methyl-1h-pyrazole-3-carbonitrile has been studied for its potential as a corrosion inhibitor for metal alloys, demonstrating its versatility in protecting metals from degradation and extending their service life in various industrial applications. This property makes it a valuable asset in the metalworking and engineering sectors.

InChI:InChI=1/C5H5N3/c1-8-3-2-5(4-6)7-8/h2-3H,1H3

Upstream product

• 89179-62-4 1-methyl-1H-pyrazole-3-carboxamide 
• 27258-32-8 1-methyl-1H-pyrazole-3-carbaldehyde 
• 36650-74-5 pyrazolecarbonitrile 
• 74-88-4 methyl iodide 
• 17827-61-1 methyl ester of 1-methylpyrazole-3-carboxylic acid 

Downstream Products

• 66121-69-5 1-methyl-1H-imidazole-4-carbonitrile 
• 45515-45-5 1-methyl-1H-imidazole-2-carbonitrile 
• 1345118-54-8 N-{5-[1-methyl-3-(5-methyl(1,2,4-oxadiazol-3-yl))pyrazol-5-yl](2-pyridyl)}(2-chlorophenyl)carboxamide 
• 612511-81-6 1-(1-methyl-1H-pyrazol-3-yl)methanamine 
• 1361379-23-8 (2-chlorophenyl)-N-{5-[1-methyl-3-(5-methyl(1,2,4,-oxadiazol-3-yl))pyrazol-5-yl](1,3-thiazol-2-yl)}carboxamide 
• 1361379-22-7 N-(2-fluorophenyl){5-[1-methyl-3-(5-methyl(1,2,4-oxadiazol-3-yl))pyrazol-5-yl](2-thienyl)}carboxamide 
• 1361379-21-6 N-(2,6-difluorophenyl){5-[1-methyl-3-(5-methyl(1,2,4-oxadiazol-3-yl))pyrazol-5-yl](2-thienyl)}carboxamide 
• 137890-10-9 1-(1-methyl-4-nitro-1H-pyrazol-3-yl)ethanone 

Relevant academic research and scientific papers

5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER

The invention is directed to substituted 5-(1H-benzo[d]imidazo-2-yl)- pyridin-2-amine and 5-(3H-imidazo[4,5-b]pyridin-6-yl)-pyridin-2-amine derivatives. Specifically, the invention is directed to compounds according to Formula (lb) wherein R', R2', R3', R4', Rs', R6', R7', and X1' are as defined herein; or a salt thereof including a pharmaceutically acceptable salt thereof. The compounds of the invention decrease MYC protein (c-MYC) in cells and/or inhibit p300/CBP histone acetyltransferase and can be useful in the treatment of cardiac hypertrophy, diabetes, obesity and nonalcoholic fatty liver disease, HIV, polycystic kidney disease, inflammatory diseases, ankylosing spondylitis, psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, cancer and pre-cancerous syndromes, and diseases associated with dysregulation of Myc or inhibition of p300/CBP histone acetyltransferase. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention still further discloses methods of reducing MYC protein (c-MYC) in cells and inhibiting p300/CBP histone acetyltransferase activity, and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

N-alkyl-cyanopyrazole synthetic method

The invention discloses an N-alkyl-cyanopyrazole synthetic method which comprises the following step of by taking 1-alkyl-1H-pyrazole formaldehyde or a derivative thereof, ammonia water, sodium bromate and acetic acid as raw materials and water as a reaction solvent to obtain N-alkyl-cyanopyrazole . The synthetic method provided by the invention is simple in technology without using extremely toxic substances, convenient in synthesis, high in yield, convenient in purification of an obtained product and beneficial to large-scale industrial production.

Nucleophilic Substitution in Quaternary Salts of NN'-Linked Biazoles and Related Systems.

Some reactions of dicationic and monocationic N,N'-linked biazoles and of quaternized 1-(N-azolyl)pyridinium ions with nucleophiles have been studied.Although the pyrrolyl nucleus has been found to be a poor leaving group in these reactions, in other cases nucleophilic attack readily takes place at an azolyl carbon atom, with subsequent elimination of the N-substituent.The 1-methyl-3-(1-methyl-1,2,4-triazol-4-ylio)benzimidazolium dication (1) reacted at room temperature with ammonium, diethylamine, methoxyde, hydroxide, and cyanide ions, and with sodium borohydride, giving in all cases the corresponding 2-substituted benzimidazoles in good yield.In the case of the 2,4,6-trimethyl-1-(2-methylpyrazol-1-io)pyridinium dication (6), the reaction with cyanide ion afforded, regioselectively, 5-cyano-1-methylpyrazole, with no trace of the isomeric 3-cyano-1-methylpyrazole.The synthesis of the cations and dications from N-aminoazoles was easily performed.The reaction of 1-aminobenzimidazole with dehydroacetic acid in aqueous hydrochloric acid gave not only the expected 1-benzimidazol-1-yl-2,6-dimethylpyridin-4(1H)-one (9), but also 3-acetyl-1-benzimidazol-1-yl-4-hydroxy-6-methylpyridin-2(1H)-one (11).In pyridine, a pyran-2,4-dione intermediate (10), isomeric to (11), was also isolated.The quaternization reactions were easily performed, but high temperatures caused cleavage of the N-N bond.