79098-59-2Relevant academic research and scientific papers
New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position
Obase, Hiroyuki,Nakamizo, Nobuhiro,Takai, Haruki,Teranishi, Masayuki,Kubo, Kazuhiro,et al.
, p. 3186 - 3197 (2007/10/02)
We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.
