79106-74-4

Upstream product

• 72831-92-6 3-(1-benzyl-4-piperidinylidene)indolin-2-one 
• 59-48-3 2-oxoindole 
• 1835-05-8 2-bromo-1-(3,4-dimethoxyphenyl)propan-1-one 
• 79098-85-4 4-(2-oxoindolin-3-yl)piperidine hydrochloride 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 79098-59-2 threo 1-<3-(3,4-dimethoxyphenyl)-3-hydroxy-2-propyl>-4-(2-oxoindolin-3-yl)piperidine 
• 79098-59-2 erythro 1-<3-(3,4-dimethoxyphenyl)-3-hydroxy-2-propyl>-4-(2-oxoindolin-3-yl)piperidine 

Relevant academic research and scientific papers

New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position

We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.