79106-75-5

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 1205-72-7 1-benzyl-4-amino-piperidine dihydrochloride 
• 79098-87-6 1-benzyl-4-(2-nitrophenylmethyl)aminopiperidine*2HCl 

Downstream Products

• 79122-21-7 threo-1-<2-hydroxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79122-21-7 erythro-1-<2-hydroxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 98767-70-5 threo-1-<2-(3,4-dimethoxyphenyl)-2-hydroxy-1-methylethyl>-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazine-3-yl)piperidine 
• 98767-68-1 1-(3,4-Dimethoxy-phenyl)-2-[4-(2,2-dioxo-1,4-dihydro-2H-2λ⁶-benzo[1,2,6]thiadiazin-3-yl)-piperidin-1-yl]-propan-1-one 
• 79098-43-4 1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazin-3-yl)piperidine 
• 79098-42-3 1-(3,4-dimethoxybenzoylmethyl)-4-(3,4-dihydro-2,2-dioxo-1H-2,1,3-benzothiadiazin-3-yl)piperidine 
• 79106-29-9 1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-31-3 1-<2-oxo-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-47-1 1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-27-7 1-(3,4-dimethoxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-46-0 1-[2-(4-Methoxyphenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-45-9 1-<2-(4-chlorophenyl)-2-hydroxyethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-44-8 1-[2-(3-Chlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79098-78-5 1-(3,4-dichlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 

Relevant academic research and scientific papers

Synthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents

A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.

Piperidine derivatives

New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.