791067-75-9Relevant academic research and scientific papers
A new preparation of 1,3,3-trimethylbicyclo[2.2.2]octan-2,6-dione, a never isolated intermediate in a total synthesis of (+)-norpatchoulenol. Formal total synthesis of (±)-iso-norpatchoulenol
La Bella, Angela,Leonelli, Francesca,De Salve, Ilse,Migneco, Luisa M.,Bettolo, Rinaldo Marini
, p. 2120 - 2124 (2004)
A new preparation and the isolation and spectroscopic characterization of 1,3,3-trimethylbicyclo[2.2.2]octan-2,6-dione (3), a so far elusive key intermediate in the Liu-Ralitsch total synthesis of (+)-norpatchoulenol ((+)-1a), is described. The preparation of 3 constitutes also a formal total synthesis of (±)-iso-norpatchoulenol ((±)-1b), since 3 is correlated to an intermediate in the Monti and co-workers synthesis of (±)-1b.
The Total Synthesis of (+)-Norpatchoulenol: Trapping of a Non-enolizable 1,3-Diketone Intermediate with a Wittig Reagent
Liu, Hsing-Jang,Ralitsch, Milan
, p. 997 - 999 (2007/10/02)
A short total synthesis of (+)-norpatchoulenol (1) has been accomplished from (+)-camphor-10-sulphonic acid (2) involving, as a key step, the trapping of a non-enolizable 1,3-diketone intermediate with a Wittig reagent.
