791073-58-0Relevant academic research and scientific papers
Study of the effect of the nature of the side chain in esters of α-amino acids on the diastereoselectivity of condensation with 5(4H)-oxazolone in the synthesis of dipeptides with N-terminal N-acetylphenylalanine
Krasnov,Zhdanova,Solieva,Sadretdinova,Bukrina,Demin,Levit,Ezhikova,Kodess
, p. 1331 - 1334 (2007/10/03)
Conditions for fast racemization of 5(4H)-oxazolones prepared from N-acylphenylalanine were found. Reactions of 4-benzyl-2-methyl-5(4H)-oxazolone with amino acid esters proceed diastereoselectively to give predominantly dipeptides comprising R-phenylalanine. The diastereoselectivity increases with complication of the structure of the side chain in the amino acid esters.
THE ASYMMETRIC HYDROGENATION OF THE α-N-ACETYLAMINOCINNAMOYL DERIVATIVE OF AMINO ACIDS WITH CHIRAL BISPHOSPHINE-RHODIUM COMPLEX
Onuma, Ken-ichi,Ito, Tomiyasu,Nakamura, Asao
, p. 481 - 482 (2007/10/02)
An optical yield of the dipeptide obtained in the title reaction is affected by a chiral amino acid moiety in the substrate.
