3082-75-5

Basic information

• Product Name: ethyl alaninate
• Synonyms: ethyl alaninate;(2S)-2-Aminopropionic acid ethyl ester;(S)-2-Aminopropionic acid ethyl;Alanine ethyl;L-Alanine ethyl;Einecs 221-380-6;ethylL-alaninate
• CAS NO: 3082-75-5
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• EINECS: 221-380-6
• Mol File: 3082-75-5.mol
• Article Data: 30

Chemical Properties

• Melting Point: 165-166.5 °C
• Boiling Point: 127.8 °C at 760 mmHg
• Flash Point: 3.5 °C
• Appearance: /
• Density: 0.987 g/cm³
• Vapor Pressure: 11mmHg at 25°C
• Refractive Index: 1.427
• PKA: 8.03±0.29(Predicted)
• CAS DataBase Reference: ethyl alaninate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl alaninate(3082-75-5)
• EPA Substance Registry System: ethyl alaninate(3082-75-5)

Safety Data

• Hazardous Substances Data: 3082-75-5(Hazardous Substances Data)

Usage

General Description

Ethyl alaninate is a chemical compound with the molecular formula C5H11NO2. It is the ethyl ester of alanine, an amino acid that is important for the production of proteins in the body. Ethyl alaninate is commonly used as a flavoring agent in the food and beverage industry due to its sweet, fruity aroma. It is also used as a precursor in the synthesis of other organic compounds. Ethyl alaninate is a clear, colorless liquid at room temperature and is soluble in water, making it versatile for a variety of industrial applications. It is important to handle ethyl alaninate with care and follow proper safety precautions, as it can irritate the skin and eyes upon contact.

InChI:InChI=1/C5H11NO2/c1-3-8-5(7)4(2)6/h4H,3,6H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 56-41-7 L-alanin 
• 122-51-0 orthoformic acid triethyl ester 
• 113693-26-8 ethyl ester of adenosine 5'-triiphospho-(P_γ-> N)-alanine 
• 60625-90-3 Cbz-alanine ethyl ester 
• 16955-04-7 ethyl (S)-2-(4-methoxyphenylamino)propanoate 
• 952524-02-6 (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole 
• 17344-99-9 AlaOEt 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 338-69-2 D-Alanine 
• 245364-50-5 (R)-N-Boc-N-o-nitrobenzenesulfonylalanine ethyl ester 
• 133467-00-2 Boc-D-alanine ethyl ester 
• 140170-75-8 (R)-2-[Benzyl-((R)-2-hydroxy-1-phenyl-ethyl)-amino]-propionic acid ethyl ester 

Downstream Products

• 23262-07-9 Cbz-glycylalanine ethyl ester 
• 5673-69-8 N-benzyloxycarbonyl-L-alanyl-L-alanine ethyl ester 
• 78346-96-0 N-(N²-benzyloxycarbonyl-L-glutaminyl)-L-alanine ethyl ester 
• 110366-83-1 N-(N^α-benzyloxycarbonyl-L-histidyl)-L-alanin-ethyl ester 
• 2749-11-3 (S)-Alaninol 
• 338-69-2 D-Alanine 
• 5625-46-7 cyclo(-DL-Ala-DL-Ala-) 
• 59903-72-9 (S)-2-[1-Phenyl-eth-(Z)-ylideneamino]-propionic acid ethyl ester 
• 74196-76-2 Ethyl N-<β-(p-propoxybenzoyl)ethyl>-D-α-alaninate hydrochloride 
• 78075-21-5 2-{Bis-[(diphenylphosphanyl)-methyl]-amino}-propionic acid ethyl ester 
• 91645-74-8 ethyl (S)-2-(N-p-toluenesulfonylamino)propanoate 
• 887231-07-4 N-2-p-Tolylthio-ethoxycarbonylglycyl-L-alanin-ethylester 
• 98365-44-7 N-2-p-Tolylthio-ethoxycarbonyl-L-alanyl-L-alanin-ethylester 
• 176844-17-0 Boc-EACA-L-Ala-OEt 

Relevant articles and documents

Synthesis and solid-state polymerization of l-alanine derivatives with a (1-pyrenyl)butadiynyl group

(1-Pyrenyl)butadiyne derivatives 5 and 6 with a methylene chain and a L-alanine moiety as a chiral group were synthesized, and the end group of 5 and 6 was ethyl ester and carboxylic acid, respectively. These compounds could be polymerized in the crystals by UV irradiation at 365 nm. The regular solid-state polymerization was confirmed for 5 although 6 showed irregular polymerization. Their nanoaggregate water dispersions were obtained by the reprecipitation method. Morphology of their nanoaggregates was studied by SEM, and helical nanoribbons and circle domains were observed for 5 and 6, respectively.

Design, synthesis and biological evaluation of novel 2-(5-aryl-1H-imidazol-1-yl) derivatives as potential inhibitors of the HIV-1 Vpu and host BST-2 protein interaction

Novel ethyl 2-(5-aryl-1H-imidazol-1-yl)-acetates 17 and propionates 18, together with their acetic acid 19 and acetohydrazide 20 derivatives, were designed and synthesized using TosMIC chemistry. Biological evaluation of these newly synthesized scaffolds in the HIV-1 Vpu- Host BST-2 ELISA assay identified seven hits (17a, 17b, 17c, 17g, 18a, 20f and 20g) with greater than 50% inhibitory activity. These hits were validated in the HIV-1 Vpu- Host BST-2 AlphaScreen and six of the seven compounds were found to have comparable percentage inhibitory activities to those of the ELISA assay. Compounds 17b and 20g, with consistent percentage inhibitory activities across the two assays, had IC50 values of 11.6 ± 1.1 μM and 17.6 ± 0.9 μM in a dose response AlphaScreen assay. In a cell-based HIV-1 antiviral assay, compound 17b exhibited an EC50 = 6.3 ± 0.7 μM at non-toxic concentrations (CC50 = 184.5 ± 0.8 μM), whereas compound 20g displayed antiviral activity roughly equivalent to its toxicity (CC50 = 159.5 ± 0.9 μM). This data suggests that compound 17b, active in both cell-based and biochemical assays, provides a good starting point for the design of possible lead compounds for prevention of HIV-1 Vpu and host BST-2 protein binding in new anti-HIV therapeutics.

Stereospecific Synthesis of 3,4-Dihydro-2 H-naphtho-1,4-oxazin-2-ones by Unification of Benzoxepine-4-carboxylates with Chiral Amino Acid Ethyl Esters

A novel and efficient stereocontrolled method has been developed for the preparation of chiral 3,4-dihydro-2H-naphtho[1,2-b][1,4]oxazin-2-ones by the reaction of benzoxepine-4-carboxylates with chiral amino acid ethyl esters for the first time. The chiral 3,4-dihydro-2H-naphtho-1,4-oxazinones have been achieved in one step by the formation of C-N, C-C, and C-O bonds.