791074-31-2

Basic information

• Product Name: (R,R)-2-acetoxyphenylmethyl-4-isopropyl-4,5-dihydro-oxazole
• Synonyms: (R,R)-2-acetoxyphenylmethyl-4-isopropyl-4,5-dihydro-oxazole
• CAS NO: 791074-31-2
• Molecular Weight: 261.321
• Mol File: 791074-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,R)-2-acetoxyphenylmethyl-4-isopropyl-4,5-dihydro-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: (R,R)-2-acetoxyphenylmethyl-4-isopropyl-4,5-dihydro-oxazole(791074-31-2)
• EPA Substance Registry System: (R,R)-2-acetoxyphenylmethyl-4-isopropyl-4,5-dihydro-oxazole(791074-31-2)

Safety Data

• Hazardous Substances Data: 791074-31-2(Hazardous Substances Data)

Upstream product

• 49845-69-4 (R)-O-acetylmandeloyl chloride 
• 51019-43-3 (R)-(-)-O-acetylmandelic acid 
• 611-71-2 (R)-Mandelic Acid 
• 791074-25-4 (R,R)-O-acetylmandelic acid (1-hydroxymethyl-2-methyl)propylamide 

Relevant articles and documents

New chiral ligands derived from mandelic acid: Synthesis and application in the asymmetric phenyl transfer reaction to an aromatic aldehyde

Starting from inexpensive enantiopure (R)- and (S)-mandelic acid, a range of α-hydroxy-2-oxazolines has been prepared. The synthesis involves the condensation of the acid chloride with a vicinal amino alcohol, followed by intramolecular cyclization to form the oxazoline ring. The resulting compounds have been used as ligands in the asymmetric phenyl transfer reaction to 4-chlorobenzaldehyde, employing a mixture of triphenylborane and diethylzinc as the phenyl source. Good yields (up to 76%) and moderate enantioselectivities (up to 35%) have been achieved.