791074-68-5Relevant academic research and scientific papers
Foldable polymers as probes
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Page/Page column 19, (2008/06/13)
Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.
To fold or to assemble?
Wang, Wei,Li, Lin-Song,Helms, Greg,Zhou, Hong-Hui,Li, Alexander D. Q.
, p. 1120 - 1121 (2007/10/03)
We introduce a new class of foldable oligomers consisting of alternating rigid and flexible regions. The rigid segments overlap to give π-stacked folded conformers whose formation is driven mostly by π-π molecular orbital overlaps. As the oligomer concentration increases, the folded molecular structures further self-assemble into larger nanostructures. The dynamic processes of folding and self-organization are monitored with absorption, fluorescence, and NMR spectroscopies. Our results show that folding dominates at low concentrations (1～ mM) and precedes self-assembly, which occurs over the initial concentration range of 1-100 mM. Copyright
