791096-46-3Relevant academic research and scientific papers
An approach to β-substituted γ-butyrolactones and its application to the synthesis of lignans
Isemori, Yuichi,Kobayashi, Yuichi
, p. 1941 - 1944 (2007/10/03)
Copper-catalyzed reaction of 4-cyclopentene-1,3-diol monoacetate with ArCH2MgCl afforded 4-arylmethyl-2-cyclopenten-1-ols regioselectively. Subsequent cleavage of the cyclopentene ring followed by functional group manipulation provided the key β-arylmethyl-γ-butyrolactones for the synthesis of lignans. In addition, synthesis of the rolipram lactone intermediate was accomplished.
