791121-61-4Relevant academic research and scientific papers
Palladium-catalyzed coupling of N-tosylhydrazones with ortho substituted aryl halides: Synthesis of 4-arylchromenes and related heterocycles
Rasolofonjatovo, Evelia,Tréguier, Bret,Provot, Olivier,Hamze, Abdallah,Morvan, Estelle,Brion, Jean-Daniel,Alami, Mouad
scheme or table, p. 1036 - 1040 (2011/03/20)
A convenient and efficient procedure for the synthesis of 4-arylchromenes, thiochromenes, and related heterocycles via a four step-sequence has been developed. The first three steps, which involve hydration of alkynes, hydrazones formation, and their Pd-c
Benzoxepin-derived estrogen receptor modulators: A novel molecular scaffold for the estrogen receptor
Lloyd, David G.,Hughes, Rosario B.,Zisterer, Daniela M.,Williams, D. Clive,Fattorusso, Caterina,Catalanotti, Bruno,Campiani, Giuseppe,Meegan, Mary J.
, p. 5612 - 5615 (2007/10/03)
We present and examine the efficacy of a novel benzoxepin-based scaffold for modulation of the human estrogen receptor. Receptor tolerance of this new molecular scaffold is examined through presentation of experimentally determined antiproliferative effects on human MCF-7 breast tumor cells and measured binding affinities. The effect of functional group substitution on the benzoxepin scaffold is explored through a brief computational structure - activity relationship investigation with molecular simulation.
