79118-16-4Relevant academic research and scientific papers
Synthesis and characterization of an unsymmetrical cobalt(III) active site analogue of nitrile hydratase
Angelosante, Jennifer K.,Schopp, Lauren M.,Lewis, Breia J.,Vitalo, Amber D.,Titus, Dustin T.,Swanson, Rebecca A.,Stanley, April N.,Abolins, Brendan P.,Frome, Michelle J.,Cooper, Lisa E.,Tierney, David L.,Moore, Curtis,Rheingold, Arnold L.,Daley, Christopher J. A.
experimental part, p. 937 - 947 (2012/05/04)
The design, synthesis, and characterization of an unsymmetrical diamidato-dithiol ligand (H4 1, where the hydrogen atoms represent deprotonatable amide and thiol protons) and its cobalt(III) complex, a synthetic analogue of the cobalt-containin
CHEMICAL COMPOUNDS
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Page/Page column 22-23, (2010/02/10)
Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may be substituted at the 5-position. The phosphoramidate moiety has attached to the P atom an aryl-O moiety and an α-amino acid moiety. The α-amino acid moiety may correspond to or be derived from either a naturally occurring or a non-naturally occurring amino acid.
Structure of Phosphorus-Containing Peptide Ligands. X-ray and NMR Structural Study of Free Ligand and Rhodium Complex
Gilbertson, Scott R.,Chen, Guohua,Kao, Jeff,Beatty, Alicia,Campana, Charles F.
, p. 5557 - 5566 (2007/10/03)
The structure of a series of phosphorus-containing peptides was studied. The X-ray structure of a phosphorus-containing dodecapeptide is reported. Analysis of the solution structure of similar phosphorus-containing peptides before and after coordination of rhodium is also reported. In both the solid state and in solution, the peptides were found to exist in a mixture of α-helical and 310 helical conformations. Coordination of rhodium to the i, i + 4 orientated phosphine groups appears to alter the conformational preference.
The effect of a peptide helix macrodipole on the pKa of an asp side chain carboxylate
Joshi, Hemant V.,Meier, Mark S.
, p. 12038 - 12044 (2007/10/03)
A study of the effect of a helix dipole on the pKa of a side chain functional group has been undertaken to determine the magnitude of these electrostatic effects in the absence of interfering influences from a protein matrix. Three helical pept
PyBOP and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib
Frerot, Eric,Coste, Jacques,Pantaloni, Antoine,Dufour, Marie-Noelle,Jouin, Patrick
, p. 259 - 270 (2007/10/02)
The difficult coupling of α-aminoisobutyric acid (Aib) was carried out using PyBOP and PyBroP in a comparative study with BOP and BroP. These reagents gave good results under simple conditions (one pot, r.t., 1h). Coded amino acids could be coupled with Aib using PyBOP under standard conditions of peptide synthesis without racemization whereas the coupling of two Aib residues required PyBroP/DMAP. A fragment containing an Aib C-terminal could be coupled without epimerization of the penultimate residue.
SYNTHESE VON 2-METHYLALANIN-PEPTIDEN, DIE pH-ABHAENGIGKEIT IHRER 13C-NMR-SPECTREN UND EINE NEUE METHODE ZUR AUSWERTUNG UEBER CS-DIAGRAMME
Leibfritz, Dieter,Haupt, Erhard,Dubischar, Norbert,Lachmann, Heinrich,Oekonomopulos, Raymond,Jung, Guenther
, p. 2165 - 2182 (2007/10/02)
The uncommon amino-acid 2-methylalanine (α-aminoisobutiryc acid, Aib) was investigated by 13C-NMR.The chemical shifts of amino- or carboxy-protected derivates of Aib and of protected oligopeptides are discussed with respect to neighbouring groups and amino acids.The pH-dependence of the 13C-NMR spectra of Aib, Aib-Ala, Ala-Aib, Aib-Ala-Aib and Aib-Ala-Aib-Ala-Aib was studied.Using these examples, a new and advantageous method is demonstrated for the first time for the evaluation of NMR titration curves, which uses so-called chemical shift diagrams (CS diagrams).
