79128-13-5Relevant academic research and scientific papers
N-(3-pyrrolidinyl) benzamide derivative
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, (2008/06/13)
N-(3-Pyrrodinyl)benzamide derivatives represented by the following general formula (I) which have potent and selective antagonism against dopamine D3 and/or D4 receptor and are useful as a psychotropic, a schizophrenia-treating agent and the like, or a pharmaceutically acceptable salt thereof or a pharmaceutical preparation thereof. STR1
METALATION REACTIONS. VI. STERIC LIMITS IN THE PREPARATION OF 1,2,3-TRI-SUBSTITUTED BENZENE DERIVATIVES
Cabiddu, Salvatore,Maccioni, Antonio,Piras, Pier Paolo,Plumitallo, Antonio
, p. 123 - 128 (2007/10/02)
Metalation of 1,3-dialkoxy-, 1-alkoxy-3-(alkylthio)- and 1,3-bis-(alkylthio)-benzenes with n-butyllithium has been examined to verify the possibility of preparing 1,2,3-tri-substituted benzene derivatives.The reaction is affected by steric hindrance.The yields of the metalation in the position ortho to both the substituents decrease as steric requirement increases becoming zero when the bulk of both the alkyl substituent and the hetero-atom is increased.It has been shown that synthesis of 1,2,3-tri-substituted derivatives by this route is feasible only with small substituents.
