79134-11-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(Methylsulfonyl)-5-nitropyridine is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and medicinal compounds.
Used in Agricultural Chemical Production:
2-(Methylsulfonyl)-5-nitropyridine serves as an intermediate in the production of agrochemicals, playing a crucial role in the creation of substances that help protect crops and enhance agricultural productivity.
Used in Dyestuff Manufacturing:
2-(Methylsulfonyl)-5-nitropyridine is utilized as an intermediate in the manufacturing of dyestuffs, contributing to the coloration and quality of various products.
Used in Optical Brighteners Production:
2-(Methylsulfonyl)-5-nitropyridine is also used in the production of optical brighteners, which are substances that enhance the appearance of materials by reflecting light more effectively, improving their visual appeal.
In all applications, due to the compound's reactivity and potential for causing irritation, it is essential to implement proper safety precautions and handling procedures to ensure the well-being of those working with 2-(Methylsulfonyl)-5-nitropyridine.

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 20885-21-6 3-nitro-6-(methylthio)pyridine 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 187143-22-2 6-(methylsulfonyl)pyridin-3-amine 
• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 1198785-18-0 2-bromo-6-methanesulfonylpyridin-3-ylamine 

Relevant academic research and scientific papers

METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

5-SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

SUBSTITUTED PYRAZOLE ANALOGUES AS RAR ANTAGONISTS

The present invention provides compounds of Formula I or a pharmaceutical salt thereof; methods of treating osteoarthritis and the pain associated with osteoarthritis using the compounds; and processes for preparing the compounds.

INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS

lndazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole-3- carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Compounds of Formula I wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

1,2,4-TRIAZOLE DERIVATIVE, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

The present invention relates to compounds of the formula wherein R2, R3, R6and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents

This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring

Pyrazole ether derivatives as anti-inflammatory/analgesic agents

The present invention relates to compounds of the formula wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.