79139-01-8Relevant academic research and scientific papers
TOTAL SYNTHESIS OF ERGOT ALKALOID, (+/-)-6,7-SECOAGROCLAVINE
Somei, Masanori,Yamada, Fumio,Karasawa, Yoshio,Kaneko, Chikara
, p. 615 - 618 (1981)
Ergot alkaloid, (+/-)-6,7-secoagroclavine was synthesized form 2-methyl-5-nitroisoquinolinium iodide by three routes.In the course of the study, a novel intra-molecular γ-alkylation of allyl alcohol was found.Reaction of Grignard reagents with nitroalkanes to afford N-alkyl hydroxylamines was effectively used in the present synthesis.
