79139-40-5

Basic information

• Product Name: Phenol, 3-methyl-4-nitro-, acetate (ester)
• CAS NO: 79139-40-5
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Mol File: 79139-40-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenol, 3-methyl-4-nitro-, acetate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-methyl-4-nitro-, acetate (ester)(79139-40-5)
• EPA Substance Registry System: Phenol, 3-methyl-4-nitro-, acetate (ester)(79139-40-5)

Safety Data

• Hazardous Substances Data: 79139-40-5(Hazardous Substances Data)

Upstream product

• 2581-34-2 3-methyl-4-nitrophenol 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 103440-91-1 1-(2-Hydroxy-4-methyl-5-nitrophenyl)ethanone 
• 343786-85-6 4-Acetoxyacet-o-toluidid 
• 128971-01-7 N,N-dioctadecyl-N-methyl-N-<2-nitro-5-oxidobenzyl>ammonium bromide 
• 147597-73-7 3-(bromomethyl)-4-nitrophenyl acetate 
• 104894-15-7 bromure de nitro-2 acetoxy-5 benzyltriphenylphosnphonium 

Relevant articles and documents

COMPOUNDS AND METHODS FOR MODULATING ACTIVITY OF CALCIUM RELEASE CHANNELS

The present teachings provide compounds of Formulae I and II: and and pharmaceutically acceptable salts, hydrates, complexes, esters, and prodrugs thereof, wherein R1, R1', R2, R2', R3, R3', and X are as defined herein. The present teachings also provide methods of making the compounds of formulae I and II, and methods of treating RyR-associated conditions, disorders, and diseases that include administering a therapeutically effective amount of a compound of formula I or II to a subject in need thereof. In addition, the present teachings relate to methods of reducing the open probability of a ryanodine receptor, and methods of reducing Ca2+ release across a ryanodine receptor (e.g., into the cytoplasm of a cell), by contacting a compound of formula I or II with a ryanodine receptor.

Synthesis and in-vitro evaluation of platelet aggregation inhibitory activity of paeonol and its analogues

Paeonol (1-(2-hydroxy-4-methoxyphenyl)ethanone) and a series of substituted 1-(2-hydroxyphenyl)ethanone derivatives were synthesized and screened as inhibitors of platelet aggregation. The compounds with the greatest anti-platelet potential among the series tested were 1-(2,5-dihydroxyphenyl)ethanone (65.36% inhibition at 300 μM against 5 μM ADP), paeonol(36.31%), 1-(2-hydroxy-5-methoxyphenyl)ethanone (24.47%), 1-(2-hydroxy-5-nitrophenyl) ethanone (30.40%) and 1-(5-chloro-2-hydroxy-4-methylphenyl)ethanone (24.43%).