79149-51-2

Upstream product

• 110-91-8 morpholine 
• 62044-37-5 4-cyanophenylacetic acid chloride 
• 1696-20-4 4-acetylmorpholine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 3058-39-7 4-iodobenzonitrile 
• 5462-71-5 4-cyanophenylacetic acid 

Downstream Products

• 79149-38-5 4-(2-Morpholin-4-yl-2-oxo-ethyl)-thiobenzamide 
• 79149-26-1 4-(2-Morpholin-4-yl-2-oxo-ethyl)-thiobenzimidic acid methyl ester; hydriodide 
• 79149-11-4 4-Amidinophenylessigsaeuremorpholidhydroiodid 

Relevant academic research and scientific papers

Palladium-catalyzed intermolecular α-arylation of zinc amide enolates under mild conditions

The intermolecular α-arylation and vinylation of amides by palladium-catalyzed coupling of aryl bromides and vinyl bromides with zinc enolates of amides is reported. Reactions of three different types of zinc enolates have been developed. The reactions of

SMALL MOLECULE LFA-1 INHIBITORS

The present invention relates to novel compounds which are capable of inhibiting the interaction of LFA-1 with its counter ligands.

The ketene-surrogate coupling: Catalytic conversion of aryl iodides into aryl ketenes through ynol ethers

tert-Butoxyacetylene is shown to undergo Sonogashira coupling with aryl iodides to yield aryl-substituted tert-butyl ynol ethers. These intermediates participate in a [1,5]-hydride shift, which results in the extrusion of isobutylene and the generation of aryl ketenes. The ketenes are trapped in situ with multiple nucleophiles or undergo electrocyclic ring closure to yield hydroxynaphthalenes and quinolines.